Regenerative Medicine and Stem Cell Isolation Technology To Get A Boost With 21st Century Cures Act

sa-brcRegenerative medicine includes a significant amount of stem cells for therapies. Stem cells are isolated from 3 locations of the human body: Bone Marrow, Umbilical Cord and adipose tissue. Until recently, cord blood and bone marrow stem cells were only known sources; however the adipose tissue is highly viable source of stem cell that is now depended on by surgeons. Adipose tissue has proven to serve as an abundant, accessible and rich source of adult stem cells with multipotent properties. In recent years there has been a sharp rise in the research of Adipose-derived Stem Cells (ASCs) for tissue engineering applications.

The U.S. Congress recently passed the 21st Century Cures Act that provides significant boost to regenerative medicine with a number of incentives for pro-innovation industrial players. It is anticipated to promote approvals for stem cell treatment with consideration of patient registries, electronic health records and other data collected outside the formal clinical trial process. Innovative companies can apply to the FDA under a new designation for treatment approval.

Stem cell isolation technology involves centrifugation systems that can extract Stromal Vascular Fraction (SVF) from adipocytes. Over 2 million liposuction surgeries are performed globally each year. Previously, the fat extracted from adipose tissue was discarded and disposed off, however with the newly found knowledge of ADSCs, there has been a spurt of companies in the stem cell isolation technology market. Major players offering devices for isolation of stem cells from adipose tissue include Cytori, Stempeutics, TerumoBCT, Tissue Genesis (Incellator), Cellular Biomedicine Group (A-Stromal ProCeller), SynGen (SynGenX-1000), BioSafe (Sepax-2), PNC International (CHA-Station) and Neogenesis (UNiStation). Approximately 500,000 bone-grafting procedures are performed each year in the United States. There are several companies offering technology to harvest stem cells specifically from bone marrow as well. These include EmCyte Corporation and Cesca Therapeutics.

The stem cell isolation technology market is anticipated to grow significantly due to increasing popularity of cosmetic surgery such as alopecia. ADSCs can also be potentially applied for treatment of erectile dysfunction. Certain companies such as Adistem provide supplementary technology to “activate” ADSCs. PhotoActivation Technology has also been used for activating adipose-derived stem cells (ASCs) for therapeutic and regenerative application since 2006.

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