Scientists construct better way to decipher genome

Scientists construct better way to decipher genome as it is the body’s diktat handbook. It entails the unprocessed information in the form of DNA that regulates everything from whether the animal walks on four legs or two to one’s possible risk for disease.

But this handbook is written in the parlance of biology so comprehending all that it encodes is slightly difficult. Now Columbia University researchers have evolved a data processing tool that throws light on genomes most difficult to render segments. With this instrument the scientists would be able to comprehend how DNA escorts from growth and development to aging and disease.


Richard Mann, PhD, a principal investigator at Columbia’s Mortimer B. Zuckerman Mind Brain Behavior Institute and a senior author of the paper said that the genome of even straightforward entity such as fruit fly entail 120 million letters worth of DNA, much of it is yet to be deciphered as the indication it provides have been too acute for existing tools to locate. He further says that however, the new algorithm let us explore through these millions of lines of genetic code and detect even the most vague signals, ensuing in a much more comprehensive picture what DNA encodes.

Geneticists have detected ways to decode the mysteries hidden in DNA. One such enigma has included a specific prevalent class of genes known as the Hox genes. Dr. Mann, who is also the Higgins Professor of Biochemistry and Molecular Biophysics (in Systems Biology) at Columbia University Irving Medical Center said that Hox genes are the body’s expert architect; they operate some of the premature and most crucial aspects of growth disparity such as where in a progressive embryo the heads and the limbs be located.