Heart rate acceleration as blood pressure plummets indicative of neurological disease

Heart rate acceleration as blood pressure plummets indicative of neurological disease as a straightforward bedside test that equal an alteration in heart rate with a decrease in blood pressure when the patient stands may assist doctors recognizes specific deteriorating brain diseases. The test could sanction premature detection of a group of deteriorative brain diseases called synucleinopathies, which include Parkinson’s disease, Lewy Body dementia, and multiple system atrophy.


Emanating from the atypical expansion of protein known as alpha-syncline in the brain, such states injure the nerves that command blood pressure and heart rate. Lead study author Lucy Norcliffe-Kaufmann, PhD, research assistant professor of neurology, neuroscience and physiology and associate director of NYU Langone Health’s Dysautonomia Center said that for the premiere time there has been a methodical study that a patient whose blood pressure drops after standing up without an escorting increase in their heart rate may have a synucleinopathy. By administering the patient’s blood pressure lying on back, then observing the alteration in the heart rate after the patient stands up, we can assist healthcare providers with answers as to whether or not the patient has this neurodegenerative disease.

Plummeting blood pressure after standing, a disorder known as orthostatic hypotension, can cause dizziness, lightheadedness and fainting. When orthostatic hypotension is because of diminished sparking of nerves that compress the blood vessels, the state is known as neurogenic orthostatic hypotension, and is an indicator characteristics failure of the autonomic nervous system.